The IL-10/STAT3/SOCS3 axis is involved in the anti-inflammatory effect of benznidazole

ALBA SOTO CATALINA; CEVEY ÁGATA; MIRKIN GERARDO; PENAS FEDERICO; GOREN NORA BEATRIZ

Mar del Plata

Congreso; Reunión Conjunta SAIC SAI SAFIS 2018; 2018

Sociedad Argentina de Investigaciones Clínicas

Chagas disease is the main cause of dilated cardiomyopathy in Latin America. During the acute infection, the inflammatory response is critical for the control of parasite proliferation and its evolution. Benznidazole (Bz),one of the anti-parasitic drugs currently used for its treatment, exerts anti-inflammatory effects. We showed previously that a low dose of Bz reduces the expression of inflammatory mediators through the inhibition of the NFκB pathway, although the mechanism involved is poorly understood. In order to clarify, and to separate the anti-inflammatory effects from its anti-parasitic properties, mouse neonatal cardiomyocytes were stimulated with10 μg/ml of LPS. The pre-treatment with 15 μM Bz increased SOCS3 expression (RT-qPCR) (p