INBIRS 24491
INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
RECENT THYMIC EMIGRANTS NAÏVE CD4+ T CELLS (CD45RA+CD31+) IN PAEDRIATRIC PATIENTS INFECTED WITH HIV AND DIFFERENT ADHERENCE TO ANTIRETROVIRAL THERAPY: A LONGITUDINAL STUDY
Autor/es:
CANDI, MARCELA; URIOSTE, ALEJANDRA; BARBONI, GRACIELA; BALBARYSKI, JEANETTE; GADDI, EDUARDO; QUIROZ, HECTOR
Lugar:
Buenos Aires
Reunión:
Congreso; LXV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2018
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
Introduction: CD31 (PECAM-1) is expressed in several cellulartypes, mediates T-cells adhesion, inhibits its activation andthe co-expression with CD45RA defines recent thymic emigrants(RTEs) naïve(N) CD4 +T cells, which have not yet undergone significanthomeostatic proliferation.Objective: to monitor RTEsN CD4+T cells in paedriatic patientsinfected with HIV with different levels of adherence to antiretroviraltherapy (ART).Material and Methods: RTEsN CD4+T cells percentage levels asmarker of immunological reconstitution, were studied in 23 patientswith HIV infection by vertical transmission, in ART, at two differenttime-points of follow-up (i,f). Flow cytometry and specific monoclonalantibodies were used. Plasma HIV RNA viral load (VL) (limit for theassay log
