Modification of the HIV-specific CD8+ T-cell Responses in an Elite Controller After Chikungunya Virus Infection

YANINA GHIGLIONE; CÉSAR TRIFONE; HÉCTOR PÉREZ; JIMENA SALIDO; NATALIA LAUFER; PATRICIA PATTERSON; GABRIELA TURK; MARÍA JULIA RUIZ; YAMILA MARTIN; HORACIO SALOMÓN

Durban

Conferencia; 21st International AIDS Conference; 2016

International AIDS Society

Background:Chikungunya virus (CHIKV), the arbovirus that causes Chikungunya fever, can produce a transient depletion of CD4+ T-cells. Here, we present data of an HIV Elite Controller (EC) who acquired CHIKV infection. Aim: to evaluate the impact of transient CD4+ T-cell depletion on the CD8+ T-cell (CTL) quality response.Methods:Three blood samples, post-CHIKV infection, were obtained at: 3 weeks (Sample 1, S1); 6 weeks (S2) and 52 weeks (S3). Other 15 EC samples were evaluated for comparison. CD4-counts, viral load (VL) and immune activation were recorded. Phenotypic (CD45RO/CCR7) and functional markers (cytokines/CD107) were evaluated to characterize the HIV-specific CTL quality. Gp120-specific IgG and IgA levels were assessed. Data was analyzed using non-parametric statistics.Results:A male HIV+ EC (median CD4-counts= 702cell/μl (574-1161), VL