HIV-1 Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis in Astrocytes

DIEGO OJEDA, JAVIER URQUIZA, JORGE QUARLERI

Durban

Conferencia; 21st International AIDS Conference (AIDS 2016); 2016

International AIDS Society

The presence of HIV-1 tissue reservoirs, located in the central nervous system, is the main support for HIV-1 chronic infection and the consequent avoidance tovirus eradication in HIV-1-infected individuals. Given the diverse pathophysiological functions of mitochondria during viral infections, understanding the role of mitochondrial dynamics and mitophagy in HIV-infected astrocytes is highly warranted. The present study addressed these challenges and revealed new and opposing phenomena on HIV-infected. Here we demostrate that HIV-1 productive infection on astrocytes can induce aberrant mitochondrial dynamicsby mitochondrial fission and subsequent complete mitophagy as a pivotal strategy to subvert imminent apoptosis due to increased mitochondrial injury.