Th17 and Tregs at Early HIV Infection Influence Disease Progression and Anti-HIV CD8+ Responses.

FALIVENE JULIANA; GHIGLIONE YANINA; LAUFER N; MARIA EUGENIA SOCIAS; RUIZ MJ; PEDRO CAHN; OMAR SUED; SALOMON H; TURK GABRIELA; GHERARDI M. MAGDALENA

Boston, MA

Congreso; Conference On Retroviruses And Opportunistic Infections,; 2014

BACKGROUND:Th17 and Treg subsets have been related to HIV/SIV disease progression. Their role and direct relation with specific HIV-adaptive T-cell responses during primary HIVinfection (PHI)are unexplored topics. Aim: To analyze Th17 and Treg subsets, their balance and correlation with clinical parameters, immune activation and specific anti-HIV responses during early infection. METHODOLOGY:PBMCs were obtained from6 healthy donors (HDs) and 28 HIV infected-subjects: 6 elite controllers (ECs),5chronics (Chs), and 17PHIs (within 6 months post-infection (mpi)). PHIs were classified as ?PHI