INBIRS 24491
INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ADRENAL AXIS DYSREGULATION INFLUENCES CD8+ T CELL DIFFERENTIATION INTO CYTOLYTIC EFFECTORS DURING HIV-MYCOBATERIUM TUBERCULOSIS COINFECTION
Autor/es:
SUAREZ, GUADALUPE; ANGERAMI, MATIAS TOMAS; VECCHIONE, MARÍA BELÉN; SUED, OMAR; LAUFER N; BEN, GRACIELA; MESH, VIVIANA; BOTTASSO OSCAR; MARÍA F. QUIROGA
Lugar:
Los Cocos, Cordoba, Argentina
Reunión:
Congreso; LXI Reunión Anual de la Soc Arg de Inmunologia; 2013
Institución organizadora:
SAI
Resumen:
Tuberculosis (TB) is the first cause of death in HIV+ patients. coinfected HIV-M. tuberculosis (Mtb) patients show higher cortisol/DHEA ratios that elicit immune alterations. We studied the effect of adrenal steroids on CD8 T cells (CD8Tc) effectors/memory distribution and function and their role during HIV-Mtb coinfection. Methods: 24 HIV+ with active TB (HIV-TB), 5 HIV+ with latent TB (HIV-TBL), 7 HIV+/PPD- (HIV) and 20 healthy (HD) subjects were studied. CD27 and CD45RA were used to identify CD8Tc memory subsets by flow cytometry and adrenocortical hormone plasma levels were measured. Data was analyzed using parametric and nonparametric tests. HIV-TB exhibited lower Naïve (Nv) and higher Effector Memory RA (EMRA) frequencies among CD8Tc compared to HD (p
