CD4+ Th17 and Treg Subsets During Acute/Early HIV Infection are Associated with Distinct Patterns of Disease Progression and anti-HIV CD8+ Responses

JULIANA FALIVENE; YANINA GHIGLIONE; NATALIA LAUFER; MARÍA EUGENIA SOCIAS; MARÍA JULIA RUIZ; PEDRO CAHN; OMAR SUED; HORACIO SALOMON; GABRIELA TURK; MARÍA MAGDALENA GHERARDI

Congreso; AIDS Vaccine 2013; 2013

Background: Th17 and Treg subsets have been related to HIV/SIV disease progression. Their role and direct relation with specific HIV-adaptive T-cell responses during primary HIV-infection (PHI) are largely unexplored topics. Aim: To analyze Th17 and Treg subsets, their balance and correlation with clinical parameters and specific anti-HIV responses during acute/early infection. Methods: PBMCs were obtained from 6 healthy donors (HDs) and 22 HIV infected-subjects: 6 elite controllers (ECs), 4 chronics, and 12 PHIs (within 6 months post-infection (mpi)). PHIs were classified as “PHI350 vs. PHI