INBIRS 24491
INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Unidad Ejecutora - UE
artículos
Título:
Computational comparison of availability in CTL/gag epitopes among patients with acute and chronic HIV-1 infection
Autor/es:
CAHN, PEDRO; CANITANO, FLAVIA; SUED, OMAR; SALOMÓN, HORACIO; PANDO, MARIA; RUIZ, MARIA JULIA; SALOMÓN, HORACIO; PANDO, MARIA; RUIZ, MARIA JULIA; DILERNIA, DARIO; DILERNIA, DARIO; TURK, GABRIELA; TURK, GABRIELA; GHIGLIONE, YANINA; GHIGLIONE, YANINA; DAMILANO, GABRIEL DARIO; DAMILANO, GABRIEL DARIO; CAHN, PEDRO; CANITANO, FLAVIA; SUED, OMAR
Revista:
VACCINE
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2018 vol. 36 p. 4142 - 4151
ISSN:
0264-410X
Resumen:
Background: Recent studies indicate that there is selection bias for transmission of viral polymorphisms associated with higher viral fitness. Furthermore, after transmission and before a specific immune response is mounted in the recipient, the virus undergoes a number of reversions which allow an increase in their replicative capacity. These aspects, and others, affect the viral population characteristic of early acute infection. Methods: 160 single gag-gene amplifications were obtained by limiting-dilution RT-PCR from plasma samples of 8 ARV-naïve patients with early acute infection (
