Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population

TRINKS, JULIETA; CAPUTO, MARIELA; HADDAD, LEILA; AMEIGEIRAS, BEATRIZ; HEINRICH, FABIANA; ECHENIQUE, GUSTAVO; ROJAS, AMALIA; FERNÁNDEZ, ROBERTO J.; NUÑEZ, FÉLIX; CORACH, DANIEL; TOKUNAGA, KATSUSHI; NISHIDA, NAO; TSUCHIURA, TAKAYO; BLEJER, JORGELINA; FRÍAS, SILVIA E.; REMONDEGUI, CARLOS; CHARRE SAMMAN, MIGUEL; MARTÍNEZ, ALFREDO; BURGOS PRATX, LEANDRO; GALDAME, OMAR; SUGIYAMA, MASAYA; MIZOKAMI, MASASHI; HULANIUK, MARÍA LAURA; MARCIANO, SEBASTIÁN; BARTOLI, SONIA; VISTARINI, CECILIA; CEBALLOS, SUSANA; D'AMICO, CLAUDIA; RIDRUEJO, EZEQUIEL; SALAMONE, HORACIO; GADANO, ADRIÁN; FLICHMAN, DIEGO

LIVER INTERNATIONAL

WILEY-BLACKWELL PUBLISHING, INC

Año: 2017

1478-3223

Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: A total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P