TRENDS IN TRANSMISSION OF DRUG RESISTANCE AND PREVALENCE OF NON-B SUBTYPES IN PATIENTS WITH ACUTE OR RECENT HIV-1 INFECTION IN BARCELONA IN THE LAST 16 YEARS (1997-2012).

JUAN AMBROSIONI; OMAR SUED; DAVID NICOLAS; MARTA PARERA; MARÍA LÓPEZ-DIÉGUEZ; ANABEL ROMERO; FERNANDO AGÜERO; MARÍA ÁNGELES MARCOS; CHRISTIAN MANZARDO; LAURA ZAMORA; MANUEL GÓMEZ CARRILLO; JOSÉ MARÍA GATELL ; TOMÁS PUMAROLA ; JOSÉ MARÍA MIRÓ

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015

1932-6203

ObjectivesTo evaluate the prevalence of transmitted drug resistance (TDR) and non-B subtypes in patients with acute/recent HIV-1 infection in Barcelona during the period 1997-2012.MethodsPatients from the ?Hospital Clínic Primary HIV-1 Infection Cohort? with a genotyping test performed within 180 days of infection were included. The 2009 WHO List of Mutations for Surveillance of Transmitted HIV-1 Drug Resistance was used for estimating the prevalence of TDR and phylogenetic analysis for subtype determination.Results189 patients with acute/recent HIV-1 infection were analyzed in 4 time periods (1997-2000, n=28; 2001-4, n=42; 2005-8, n=55 and 2009-12, n=64). The proportion of patients with acute/recent HIV-1 infection with respect to the total of newly HIV-diagnosed patients in ourcenter increased over the time and was 2.18%, 3.82%, 4.15%and 4.55% for the 4 periods, respectively (p=0.005). The global prevalence of TDR was 9%, or 17.9%, 9.5%, 3.6% and 9.4% by study period (p=0.2). The increase in the last period was driven by protease-inhibitor and nucleoside-reverse-transcriptase-inhibitor resistance mutations while non-nucleoside- reverse-transcriptase inhibitor TDR and TDR of more than one family decreased. The overall prevalence of non-B subtypes was 11.1%, or 0%, 4.8%, 9.1% and 20.3 by study period (p=0.01). B/F recombinants, B/G recombinants and subtype F emerged in the last period. We also noticed an increase in the number of immigrant patients (p=0.052). The Proportion of men-who-have-sex-with-men (MSM) among patients with acute/recent HIV-1 infection increased over the time (p=0.04).ConclusionsThe overall prevalence of TDR in patients with acute/recent HIV-1 infection in Barcelona was 9%, and it has stayed relatively stable in recent years. Non-B subtypes and immigrants proportions progressively increased.