ACTIONS OF 17beta-ESTRADIOL AND TESTOSTERONE IN THE MITOCHONDRIA AND THEIR IMPLICATIONS IN AGING

ANDREA VASCONSUELO; LORENA MILANESI ; RICARDO BOLAND

AGEING RESEARCH REVIEWS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2013 vol. 12 p. 907 - 917

1568-1637

A. Vasconsuelo y L. Milanesi: Igual contribución al trabajo A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.