17beta;-estradiol and testosterone in sarcopenia: role of satellite cells

LA COLLA, ANABELA; PRONSATO, LUCÍA; LORENA MILANESI; ANDREA VASCONSUELO

AGEING RESEARCH REVIEWS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2015 vol. 24 p. 166 - 177

1568-1637

Abstract: The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalentcondition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear,evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsiblefor muscle perfomance decline. Interesting, sarcopenia has been associated to a deficit of sex hormoneswhich decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not bepossible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They areactivated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cellscould be a key factor to overcome sarcopenia. The importance, satellite cells are 17β-estradiol (E2) andTestosterone (T) targets. In this review, we discuss potential mechanisms through which sex steroidsregulate satellite cells and consequently the effects of E2 and T in aged skeletal muscle, outlining newadvances in understanding and potential therapeutic avenues to alleviate sarcopenia or othermyopathies associated to desregulation apoptosis by disbalance hormonal.