CARDIAC ELECTROPHYSIOLOGICAL CHANGES LINKED TO VITAMIN D RECEPTORS DEFICIENCY IN OBSTRUCTIVE NEPHROPATHY

LEÓN FERDER; EMILIANO DIEZ; LILIANA ALTAMIRANO; ISABEL MERCEDES GARCÍA; LUCIANA MAZZEI; AMIRA PONCE ZUMINO; WALTER MANUCHA

New Orleans

Congreso; High Blood Pressure Research 2013; 2013

Background: Chronic kidney disease is highly prevalent and is associated with cardiovascular disease. Paricalcitol protects individuals from some of the renal and cardiovascular complications associated with kidney disease. However, its electrophysiological effect during myocardial ischemia-reperfusion is currently unknown. Aims: Using an obstructive nephropathy (ON) model, we plan to investigate the potential, structural, and functional changes of the heart that are linked to vitamin D deficiency. Methods: The ureters of adult rats (n = 10) were unilaterally obstructed. An inductor of the vitamin D receptor (VDR) was administered for 15 days (30ng/Kg/day, ip). We evaluated histological, molecular, and biochemical parameters, as well, cardiac electrophysiological activity with ischemia-reperfusion protocol. Results: we found changes in the action potential duration (APD) at 90% (* P