INVESTIGADORES
MANUCHA Walter Ariel Fernando
artículos
Título:
Position statement. Effect of SGLT2-i on blood pressure, vascular damage, kidney disease, and associated cardiovascular risk
Autor/es:
WALTER MANUCHA; LEÓN FERDER; ALICIA JAWERBAUM; MARCELO CHOI
Revista:
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE
Editorial:
ASOC REGIONAL DIALISIS TRASPLANTES RENALES
Referencias:
Lugar: Buenos Aires; Año: 2024
ISSN:
0326-3428
Resumen:
A surprising new paradigm has been established with the advent of "gliflozins". Beyond their antihyperglycemic action, these drugs have significantly impacted the therapeutics of cardio-vascular-renal-metabolic disorders responsible for the most prevalent diseases we address in clinical practice. Sodium-glucose cotransporter type 2 (SGLT-2 i) inhibitors help control and reduce the progression of target organ damage.In this Statement of Position, four of the Argentinean Medical Societies linked to these issues agreed to reflect the knowledge of this hopeful phenomenon generated by more than 7,500 publications published in the last ten years on the benefit of "gliflozins". We decided to rigorously review the experimental evidence and the multiple controlled works showing its metabolic, vascular, cardiac, renal, and cellular effects, including unresolved aspects and warnings about the precautions in its use.
