INVESTIGADORES
MANUCHA Walter Ariel Fernando
artículos
Título:
EPIGENETIC MECHANISMS INVOLVED IN INFLAMMAGING-ASSOCIATED HYPERTENSION
Autor/es:
VINÍCIUS AUGUSTO SIMÃO; LEÓN FERDER; WALTER MANUCHA; LUIZ GUSTAVO DE ALMEIDA CHUFFA
Revista:
CURRENT HYPERTENSION REPORTS
Editorial:
CURRENT MEDICINE GROUP
Referencias:
Año: 2022 vol. 24 p. 547 - 562
ISSN:
1522-6417
Resumen:
Purpose of ReviewThis review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered.Recent findings Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and many others. More recently, a series of noncoding RNAs, mainly microRNAs, have been described as possessing epigenetic actions on the regulation of inflammasome-related hypertension, emerging as a promising therapeutic strategy.Summary: Although there are a variety of pharmacological agents that effectively regulate inflammaging-related hypertension, a deeper understanding of the epigenetic events behind the control of vessel deterioration is needed for the treatment or even to prevent the disease onset.
