CONICET | Buscador de Institutos y Recursos Humanos

BackgroundCardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology and other related CVD has been revalued. ObjectivesTo quantify and evaluate inflammatory markers such as ultra-sensitive C-reactive protein (uCRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and heat shock protein 70 (Hsp70) in the serum of patients with HF and to compare them with healthy individuals, also correlating the values obtained with oxidative stress markers and nitric oxide (NO) bioavailability previously investigated in these patients, as well as with the coexistence or not of secondary pulmonary hypertension (SPH) associated with HF. MethodsThe determination of all parameters was achieved with standardized, reproducible, accurate and affordable biochemical methods. ResultsThe values obtained for uCRP, IL-6 and TNF-α were following the pattern of oxidative markers previously found in these patients. These findings expose the coexistence of oxidative stress and inflammation during HF. Of particular interest, such markers are more exacerbated when were associated with SPH, increasing its value as possible biomarkers in this pathology. However, the found levels of Hsp70 were controversial. ConclusionThe pattern of oxidative-inflammatory markers suggests their value as possible biomarkers in this cardiovascular disease. Nevertheless, additional studies are needed to assess in greater detail the importance of the relationship between serum Hsp70 expression and SPH-associated or non-SPH morbidity in HF.

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