On the negative feedback of extracellular ADP on ATP release: a theoretical approach

CHARA OSVALDO; PAFUNDO DIEGO; SCHWARZBAUM PABLO JULIO

Buzios, Brazil

Congreso; VII Iberoamerican Congress of Biophysics 2009; 2009

Under hypotonicity goldfish hepatocytes swell followed by avolume regulatory decrease (RVD). The initial swelling triggersATP release, followed by activation by extracellular ATP of asignaling process enabling RVD. ATP can also be hydrolysed byectonucleotidases to ADP in the extracellular space. Sinceextracellular ADP has been postulated to inhibit ATP release, weused mathematical modeling to assess whether extracellular ADPcan inhibit the release of ATP.