DRUGS-INFLUENCE ON VISCOSITY FINGERING IN A HELE-SHAW CELL.

CATTONI DIEGO; HAGER ALFREDO; DE PAOLI TOMÁS; CHARA OSVALDO

Buenos Aires, Argentina

Congreso; XIV International Biophysics Congress; 2002

IUPAB - SAB

DRUGS-INFLUENCE ON VISCOSITY FIN­GERING IN A HELE-SHAW CELL. Diego Ignacio Cattoni1, Alfredo Hager2, Tomas De Paoli2, Osval-do Chara3; ´Universidad de Buenos Aires - Facultad de Farmacia y Bioqufmica, Junfn 956, Buenos aires, 1040 Argentina, 2Catedra de Fisica - Facultad de Farmacia y Bioqufmica, Jum´n 956, Buenos Aires, 1113 Argentina, Argentina, 3Universidad de Buenos Aires-Facultad de Medicina, Argentina In this work, it was studied, the influence that some drugs could have on the hydrodynamic behavior that shows an inter-phase between two fluids. The device in which this work was done is an adaptation of the Hele-Shaw cell and it conforms a pseudo 2-dimmensional geometry. In this device it was first injected a liquid (glycerin) and then a water solution. Consistently with the litera­ture, when the first liquid injected was more viscous than the second it was observed the presence of unstabilities in the inter-phase (Saffman-Taylor unstabilities), as the experiment went by these unstabilities generated viscosity fingering. These fingers conformed patterns that were characterized geometrically and cinematically. It was studied the dependence of the waves-length of the fingers (X) with the volume flux (Q) and the time (t). The replacement of water-solution by different drugged water-solution showed in some cases alterations of the viscosity fingering pattern. It was studied the variation of the relation X= f(t) at fixed Q and X= f(Q) at fixed t between the solution with and without drugs. We think that, the use of viscosity fingering analysis in a Hele-Shaw cell, may be a sensitive system to characterize qualitatively the presence of some drugs at determined concentration ranges.