Cytoplasmic ribonucleoprotein foci in eukaryotes: hotspots of bio(chemical)diversity

LAYANA CARLA; FERRERO PAOLA; RIVERA-POMAR ROLANDO

COMPARATIVE AND FUNCTIONAL GENOMICS

HINDAWI PUBLISHING CORPORATION

Lugar: New York; Año: 2011 p. 1 - 12

1531-6912

Presentado y evaluado en 2011. Publicado online actualmente. Solicito se considere producción del período a analizar. The life of an mRNA from transcription, splicing, transport, translation to degradation offers multiple control check points that regulate gene expression. Transcription, splicing and translation have been widely studied for many years, however, in recent years, new layers of postranscriptional and postranslational control arose that involve the regulation of the metabolism of mRNA in cytoplasmic foci. They are collections of ribonucleoprotein complexes that, in most cases, remain still uncharacterized, except the processing bodies (PB) and stress granules (SG), which have been studied (and reviewed) in detail. A challenging prospective is to know how many different classes of foci exist, which functions they support, how are they formed, and how do they relate one to each other. Here we present an update of the component of the different granules, a possible function and, hypothesis on their in vivo dynamics related to translational control.