Successful use of three-dimensional conformal radiotherapy as adjuvant treatment for alveolar soft part sarcoma. A case report

OCOLOTOBICHE, ELIANA EVELINA; PÉREZ-DUHALDE, ESTEBAN; GÜERCI, ALBA MABEL

Revista de la Facultad de Medicina

Universidad Nacional de Colombia

Lugar: Bogotá; Año: 2021 vol. 70

0120-0011

Introduction: Alveolar soft part sarcoma is a very rare and aggres sive type of sarcoma. Although its histology and genetic characteristics have been identified, the benefits of adjuvant radiotherapy for its treat ment are still being studied.Case presentation: In November 2007, a 21-year-old woman pre sented with a primary tumor in the right thigh, with histological and im munohistochemical confirmation of an alveolar soft part sarcoma, which was totally resected in December 2007. Also, the large size of the mass suggested an unfavorable evolution. Two years after the first surgery, two metastatic tumors were detected in the right lung, which were com pletely resected separately. Two years later, the patient had two indepen dent relapse events, five months apart: a mass in the right tight, and a metastatic tumor in the adrenal gland together with relapse in the tight. All tumors were successfully resected. In June 2014, after the last local relapse, adjuvant radiotherapy was started because of the risk of thigh amputation. At the end of treatment, the patient?s general condition was good. Currently, at age 34, the patient is monitored through periodic eval uations, showing disease regression and stabilization.In press publication Conclusions: Currently, it is known that radiation not only produces cytotoxic effects on the target region, but also induces an immune sys tem-mediated systemic response with potential antimetastatic properties. The emerging radiobiological paradigms should be considered, particu larly since they could explain some encouraging and unexpected results such as those described in this case.