SINGLE NUCLEOTIDE POLYMORPHISMS IN ATM, TNF-α AND IL6 GENES AND RISK OF RADIOTOXICITY IN BREAST CANCER PATIENTS

CÓRDOBA ELISA; LACUNZA EZEQUIEL; ABBA MARTIN; EDUARDO FERNÁNDEZ; GÜERCI ALBA

MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018

1383-5718

Although oncological therapies have improved in the last decades, breast cancer remains a serious health problem worldwide. RT is one of the most frequent treatments. While the goal of this therapy is to eliminate tumor cells, it can also alter the surrounding normal tissue, especially the skin. These reactions may vary between patients, both by extrinsic and intrinsic factors. In this way the objective of this work was to evaluate the association of gene polymorphisms involved in central phenotype pathways such as ATM, IL6 and TNF and the establishment of individual radiosensitivity in patients with breast cancer who presented an exacerbated response to RT.Although the univariate analysis between the polymorphisms did not demonstrate a significant association with this trait, the analysis of interaction between polymorphisms reveals that there is an increased risk of patients presenting together: wild genotype of TNF-α- G-308A and mutated genotype Of IL6G-174C and heterozygous genotype of TNF-αG-308A and heterozygous genotype of IL6G-174C.On the other hand, eloquent results demonstrate that breast size and patient age are extrinsic factors that influence the determination of the acute effects associated with RT. Because the trait is multifactorial, together with the establishment of polymorphisms of particular interest, elements of significance that contributes as external factors in the determination of individual radiosensitivity as a phenotype should be considered together.