INVESTIGADORES
GÜERCI Alba Mabel
artículos
Título:
Chronic exposure to low-dose of X-rays induces
Autor/es:
CLAUDIA GRILLO AND ALBA GÜERCI
Revista:
Int. J. Low Radiation
Editorial:
Inderscience Enterprises Ltd
Referencias:
Año: 2011 vol. 8 p. 198 - 213
ISSN:
1741-9190
Resumen:
The purpose of present study is to evaluate the induction of
clastogenic effect after chronic exposure to low dose of ionising radiation in
both CHO-K1 cells and in their DNA Double-Strand Breaks (DSBs)-repair
deficient mutant xrs-5. Cells were cultured for 14 dilution cycles and grown to
confluency. Radiation treatment was performed once per cycle with 10 mGy
X-rays to carry out the structural chromosome aberration test. The results
showed a significant increase in the frequency of achromatic lesions
(p < 0.001) in CHO-K1 cells. In addition, xrs-5 cells showed an increase of
chromatid and chromosome-type aberrations (p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
chromatid and chromosome-type aberrations (p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
chromatid and chromosome-type aberrations (p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
chromatid and chromosome-type aberrations (p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
p < 0.001) in CHO-K1 cells. In addition, xrs-5 cells showed an increase of
chromatid and chromosome-type aberrations (p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.
p < 0.001). Sequential exposure
produced a level of DNA damage that is amplified through successive cycles
triggering the efficient repair of DSBs. The increased damage in xrs-5 cells
provides evidence that the non-homologous end-joining repair of DNA DSBs
is involved after low dose X-ray exposure.