INVESTIGADORES
RUBIANES Maria Dolores
artículos
Título:
Peptide-Based Biomaterials. Linking L-Tyrosine and Poly L-Tyrosine to Graphene Oxide Nanoribbons
Autor/es:
JOSÉ M. GONZÁLEZ-DOMÍNGUEZ; FABIANA A. GUTIÉRREZ; JAVIER HERNÁNDEZ; ALEJANDRO ANSON-CASAOS; MARÍA D. RUBIANES; GUSTAVO A. RIVAS ; M. TERESA MARTÍNEZ
Revista:
Journal of Materials Chemistry B
Editorial:
Royal Society of Chemistry
Referencias:
Lugar: Cambridge; Año: 2015 vol. 3 p. 3870 - 3884
ISSN:
2050-750X
Resumen:
Peptide-based
biomaterials are being studied actively in a variety of applications in
materials science and biointerface engineering. Likewise, there has been
ongoing exploration over the last few decades into the potential biological
applications of carbon nanomaterials, motivated by their size, shape, structure
and their unique physical and chemical properties. In recent years, the
functionalization of carbon nanotubes and graphene has led to the preparation
of bioactive carbon nanomaterials that are being used in biomedicine as
structural elements and in gene therapy and biosensing. The resent study proposes
different strategies for the bonding of L-tyrosine and the homopolypeptide
poly- L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment
of L-tyrosine was undertaken by amidation of the a-amine group of tyrosine with
the existing carboxylic groups in GONR and by means of esterification through
phenol nucleophiles contained in their side chains. In both cases use was made of
protective groups to address the functionalization with the desired reactive
groups. The linking of GONRs to the PTyr was attempted according to two
different strategies: either by ester bonding of commercial PTyr through its
phenol side groups or by in situ ring-opening polymerization of an N-carboxyanhydride
tyrosine derivative (NCA-Tyr) with Tyr- functionalized GONRs. These
biofunctionalized nanomaterials were characterized by Raman and infrared
spectroscopies, X-ray photoelectron spectroscopy, thermogravimetric analysis,
transmission electron microscopy, fluorescence and lectrochemical techniques. On the basis of
their properties, prospects for the potential utilization of the prepared
hybrid nanomaterials in different applications are also given.