CONICET | Buscador de Institutos y Recursos Humanos

Despite all the advances in understanding the pathogenesis of infectious diseases and the development of novel treatments and vaccines to control and prevent them, these pathogenic disorders are among the most common reasons for hospitalizations and death worldwide. Nanotechnology has recently emerged as a promising tool in biomedicine research. An important branch of nanotechnology is drug delivery and drug targeting using a wide range of biomaterials with promising potential applications in many infectious diseases.Solid lipid nanoparticles (SLNs) have emerged as carriers for therapeutic drugs, peptides, proteins, antigens and bioactive molecules as well as for vaccine delivery. They are constituted of a solid matrix that would allow the controlled release of the drug or other molecules accommodated between fatty acid chains. A summary of the nanomaterials used for the preparation of SLNs will be detailed. The current state of the art of several SLNs formulations as nanocarriers of FDA-approved drugs for the therapy and prophylaxis of many infectious diseases, including those considered as neglected by the World Health Organization that are under pre-clinical or clinical trials will be included in this chapter.

enviar mensaje