INVESTIGADORES
GAVERNET Luciana
artículos
Título:
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Autor/es:
PIZZO CHIARA; SAIZ CECILIA; TALEVI ALAN; GAVERNET LUCIANA; PALESTRO PABLO; BELLERA CAROLINA; BRUNO BLANCH LUIS E.; BENITEZ DIEGO; CAZZULO JUAN; CHIDICHIMO AGUSTINA; WIPF PETER; MAHLER GRACIELA
Revista:
CHEMICAL BIOLOGY & DRUG DESIGN
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011 vol. 77 p. 166 - 172
ISSN:
1747-0277
Resumen:
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-a,b-unsaturated esters were synthesized, and their in vitroactivity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at37 lM concentration in the enzyme assay. Computational tools and docking were used to correlatethe biological response with the physicochemical parameters of the compounds and their cruzipaininhibitory effects.
