INVESTIGADORES
GAVERNET Luciana
artículos
Título:
Design, synthesis, and anticonvulsant activity of some sulfamides
Autor/es:
GAVERNET LUCIANA; BARRIOS IVANA A.; SELLA CRAVERO MARIANA; BRUNO-BLANCH LUIS E.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Referencias:
Año: 2007 vol. 15 p. 5604 - 5614
ISSN:
0968-0896
Resumen:
As part of our search for potential anticonvulsant agents, a set of compounds were designed, synthesized, and evaluated against MES and PTZ tests. Bioisosteric functional group information was used to design a new functionality, sulfamides, that complies with the requirements of the pharmacophore previously defined. Some of the molecules showed a promising anticonvulsant profile as selective anti-MES drugs, being active at low concentrations (30 mg/kg). The biological data were confirmed in Phase II of the Anticonvulsant Drug Development Program of the National Institute of Health.
