EFFECT OF PROANTHOCYANIDIN ENRICHED FRACTION OF LIGARIA CUNEIFOLIA (PLC) ON PLASMATIC LIPID PROFILE OF WISTAR RATS FED WITH A HIGH FAT DIET (HFD)

FISCH JULIAN; CONSTANZA GIACOSA; DANIEL ELEAZAR FRANCÉS; MONTI JUAN A; LEDA URLI; ALICIA DOMINIGHINI; M. TERESA RONCO; M. WAGNER; CARNOVALE C.; ALEJANDRA LUQUITA

Congreso; REUNION ANUAL SOCIEDADES DE BIOCIENCIA 2019; 2019

Abstract/Resumen: Previously, our group demonstrated thatLigaria cuneifolia (Lc) crude extract increased blood viscosity anddecreased plasma cholesterol levels in rats. In the present study,we analyzed the effect of PLc on plasmatic lipid profile in adultmale Wistar rats hyperlipemic. Rats aged 70 days were fed with:standard diet (Control, C; n= 5), standard diet added with 40 %bovine meat juice during 28 days (HFD; n= 10). At the end ofthis time, the rats were injected i.p. each 24hr either withphysiological solution (HFD, n=5, and also the C rats) or PLc3mg/100g body weight HFD only (HFD+PLc; n= 5) during 7days. At day 8 after treatment, rats were anaesthetized i.p. withKetamine/Xylazine (100mg/kg and 3mg/kg, respectively) toobtain blood samples by cardiac puncture. Plasma assays: Cho(enzymatic method with cholesterol oxidase esterase) and TG(enzymatic methods) Plasma (mean ± SE): Cho (mg%): C:138.8 ± 14.8 HFD: 203.3 ± 21.5*; HFD+PLc: 119.5 ± 28.5#;TG: C: 170.7 ±18.5 HFD: 274.7 ± 30.7*; HFD+PLc: 190.50 ±21.65# (*p