INBIOMED 24026
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
GLIAL METABOTROPIC GLUTAMATE RECEPTOR (mGlu3R) DYSFUNCTION IN ALZHEIMER´S: IMPLICATIONS FOR sAPPα-MEDIATED Aβ CLEARANCE
Autor/es:
TURATI, JUAN; SABA JULIETA; SARAVIA FLAVIA; MARÍA JULIETA RUDI; CARNIGLIA LILA; BEAUQUIS JUAN; DURAND DANIELA; RAMÍREZ DELIA; CARUSO CARLA; LASAGA MERCEDES
Lugar:
Córdoba
Reunión:
Congreso; XXXIII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2018
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Astroglial mGlu3R promotes neuroprotective effects, such as releasing neurotrophin sAPPα and increasing Aβ uptake. We aimed to study whether mGlu3R alterations could be associated with AD progression in an AD mice model. Evidence for mechanisms involved in sAPPα-mediated Aβ elimination is provided here as well. mGlu3R protein levels remain stable during aging in non-transgenic (NTg) mice, whereas they progressively decrease with age in PDAPP-J20 (Tg) animals (p
