L-3,4-Dihydroxyphenylalanine (L-Dopa) Modulates the Function of Corticotrophs

SANTIAGO JORDI ORRILLO; JIMENA FERRARIS; FERNANDA DE FINO; NATALY DE DIOS; DANIEL PISERA

Ciudad de Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica

L-3,4-DIHYDROXYPHENYLALANINE (L-DOPA) MODULATES THE FUNCTION OF CORTICOTROPHS Santiago Jordi Orrillo (1), Nataly De Dios (1), Fernanda Defino (2), Jimena Ferraris (1), Daniel Pisera (1) (1) INBIOMED - UBA CONICET. (2) ININFA - UBA CONICET L-Dopa plus peripheral inhibitors of aromatic L-amino acid decarboxylase (AADC) is the treatment intended to alleviate the motor symptoms of Parkinson?s disease (PD). However, in patients this chronic treatment has been described to alter the secretion of ACTH, probably generating an inadequate neuroendocrine stress response. In the present research, we aimed to understand the actions of L-Dopa in the corticotroph function. In first place, we determined the effects of L-Dopa and its decarboxylation to Dopamine (DA) by AADC on ACTH secretion. We observed that L-Dopa decreases ACTH secretion in vitro (p