Metagenomic analysis of the human gut microbiome in non-treated plaque psoriasis patients

FLORENCIA GILIBERTO; IGNACIO DEI-CAS; PENAS STEINHARDT,ALBERTO

Milan

Congreso; 24th World Congress of Dermatology (WCD); 2019

ABSTRACT CONGRESO MUNDIAL DERMATOLOGÍA 2019Metagenomic analysis of the human gut microbiome in psoriasisObjective: Psoriasis is a chronic, immune-mediated inflammatory skin disease. Gut microbiota is implicated in the maturation of the host immune system and in many fundamental metabolic pathways. Imbalance of gut microbial populations or dysbiosis has important functional consequences and is implicated in many diseases. The aim of this study was to investigate whether there were differences in gut microbiota in psoriasis patients vs non-psoriasis controls and between psoriasis severity groups. Patients and methods: 55 untreated plaque psoriasis patients (28 with mild disease and 27 with moderate to severe disease defined by PASI and BSA ≥10 and IGA 2). According to psoriasis severity, we found that severe psoriasis patients had lower biodiversity than mild psoriasis patients (p: 0.049). No differences for beta diversity were found.Conclusion: These results demonstrated that there were differences in gut microbiota in patients with psoriasis. Thus, the role of the gut microbiome in psoriasis pathogenesis and the associated immune response merits further study.