Regression of an ossifying fibroma of the tibia after a fracture involving the lession. Possible role of the periostina.

MASTAGLIA SR; MAUTALEN C

Clinical Cases in Mineral and Bone Metabolism.

CCI Edizione Internazional

Año: 2015 vol. 12 p. 262 - 264

1724-8914

Ossifying fibroma (OF) ofthe long bones is a benign fibro-osseous lesion typically seen in the firstdecade of life. Ossifying fibroma usually progresses until the age of 10 years,but is occasionally found to regress spontaneously after puberty. Thepathogenesis of OF is unknown; however, it has been suggested that the basicdefect is in the periosteum. We present the radiological course of an OF of thetibia in a young patient, showing a rapid almost complete regression of thelesion after a tibial fracture at the lesion site. We postulate that the fracture-induced activationof the periosteum in a growing skeleton was fundamental to the regression ofthe lesion.