Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases

MIRAGLIA M.C; SCIAN R; C. GARCÍA SAMARTINO; BARRIONUEVO P; RODRIGUEZ A. M; A. E. IBAÑEZ; CORIA LM; VELÁSQUEZ, LIS; BALDI PABLO. C; CASSATARO J; DELPINO MARÍA VICTORIA; GIAMBARTOLOMEI GUILLERMO

JOURNAL OF NEUROINFLAMMATION

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2013 vol. 10 p. 1 - 14

1742-2094

Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology.