TNFR1 SIGNALING DRIVES THE IMMUNOSUPPRESSIVE FUNCTION OF MDSC DURING Staphylococcus aureus SEPSIS

GONZALEZ C; LEDO C; GOMEZ MI; PONCINI C

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

TNF-α signaling is strongly associated with the inflammatory response that characterizes the initial phase of sepsis. The events that govern the concomitant and subsequent immunosuppression, however, are not completely elucidated. Myeloid derived suppressor cells (MDSC) have been described as an immature population of cells that is able to suppress T cell responses. It has been described that TNF-α participates in MDSC accumulation and activation during chronic inflammation. The aim of this study was to determine the role of MDSC and TNFR1 signaling in the modulation of T cell function during S. aureus sepsis. We used a murine model of S. aureus sepsis of peritoneal origin. At day 8 after inoculation, a significant increase in the percentage of MDSC accumulated in the spleen (p