Progress on research of microRNAs from parasitic tapeworms

ROSENZVIT M.; MACCHIAROLI, NATALIA; KAMENETZKY L; CUCHER M; PÉREZ MG; ANCAROLA E

Quilmes

Congreso; II Reunión Argentina de Biología de ARNs no codificantes; 2018

RABAnc

Tapeworms (Cestoda) are etiological agents of neglected diseases such as cystic/ alveolar hydatidosis and neurocysticercosis. microRNAs (miRNAs) have emerged as a major class of regulatory genes present in most metazoans and are important for a diverse range of biological functions. Our team identified miRNAs in tapeworms for the first time and reported differential expression among developmental stages and species by means of smallRNAseq and big data analysis. We also analysed the differential expression profile of Taenia crassiceps cysticerci in presence of praziquantel (PZQ), an antiparasitic drug commonly used for tapeworms? infections.