Early administration of enalapril prevents diastolic dysfunction and ventricular remodeling in rabbits with myocardial infarction

WILENSKY L; GELPI RJ; GONZALEZ GE; MORALES C; CASSAGLIA P

CARDIOVASCULAR PATHOLOGY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2016 vol. 25 p. 208 - 213

1054-8807

ABSTRACT We aimed to investigate the role of early administration of Enalapril (Enal) on post myocardial infarction (MI) ventricular remodeling and diastolic dysfunction in rabbits. White New Zealand rabbits underwent to coronary artery ligature or Sham were divided in 3 experimental groups: 1) sham; 2) MI and 3) MI+Enal. Enal was given by gavage at a dose of 10 mg kg-1 day-1 starting at 3 hours after surgery for 35 days. At the end of the protocol we measured: 1) Mean arterial pressure; 2) Left ventricular (LV) +dP/dtmax; 3) LV end diastolic pressure (LVEDP) and Isovolumic relaxation (Tau); 4) LV dimensions; 5) LV Ejection and shortening fraction; 6) Infarct size (Masson trichrome stained slices); 7) Fibrosis in the infarct and remote zone (Picrosirius red stained slices) and; 8) Myocyte cross sectional area (MCSA) in WGA stained section. Enal reduced the mean arterial pressure by 30 % as compared with untreated animals and Sham (p