Hemin treatment potentiates CD8+ T cell proliferation and effector function and impacts upon in vivo prostate cancer progression

JAWORSKI, FELIPE MARTÍN; GENTILINI, LUCAS; GUERON GERALDINE; COMPAGNO DANIEL; VAZQUEZ, ELBA SUSANA & LADERACH, DIEGO JOSÉ

CABA

Congreso; SAI-FAIC 2015; 2015

Inflammatory microenvironments have been increasingly recognised as a risk factor for prostate cancer (PCa) and, in this regard, we have previously shown that modulation of inflammation-induced Heme Oxygenase-1 (HO-1) profoundly impacts different aspects of disease progression. The present work focuses on the role of stromal HO-1. Subcutaneous TRAMP-C1 (TC1) tumours growing in syngeneic C57BL/6 mice displayed increased tumour latency (12 days; P