IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A TRADE-OFF BETWEEN ENERGY FLUX THROUGH AMINO ACID METABOLISM AND PROTEIN SEQUENCE DIVERSITY
Autor/es:
KRICK T; SHUB DA; VERSTRAETE N; FERREIRO DU; ALONSO, LG; SHUB M; SÁNCHEZ IE
Lugar:
Puerto Varas
Reunión:
Congreso; 2013 Latin American Protein Society Meeting; 2013
Institución organizadora:
Latin American Protein Society
Resumen:
The twenty amino acids present different relative abundances in proteomes. Abundances are conserved across organisms, suggesting a single underlying principle. We postulate that maximizing sequence diversity and minimizing amino acid cost are both advantageous for an organism. Fulfilling these two conditions predicts a relationship between energy flux through amino acid metabolism and amino acid abundance. Our theory reproduces the relative abundances of amino acids in over 100 proteomes with surprising accuracy and better than a cost-naïve model based on the genetic code.
