Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test

GARGIULO, AUGUSTO P.I.; GARGIULO, ANGEL J.M.; LAFUENTE, JOSÉ V.; GARGIULO, PASCUAL A.; GARGIULO, MERCEDES M.L.; BAIARDI, GUSTAVO C.; GUEVARA, MANUEL A.; GARGIULO DE ARANDA, MARÍA P.; ACUÑA, ANDRES; LANDA DE GARGIULO, ADRIANA I.; GARGIULO, AUGUSTO P.I.; GARGIULO, ANGEL J.M.; LAFUENTE, JOSÉ V.; GARGIULO, PASCUAL A.; GARGIULO, MERCEDES M.L.; BAIARDI, GUSTAVO C.; GUEVARA, MANUEL A.; GARGIULO DE ARANDA, MARÍA P.; ACUÑA, ANDRES; LANDA DE GARGIULO, ADRIANA I.

Journal of Basic and Clinical Physiology and Pharmacology

Walter de Gruyter GmbH, Berlin/Boston

Lugar: Berlin/Boston; Año: 2018 vol. 0 p. 1 - 6

0792-6855

Background:In previous studies, we have observed that specific N-methyl-d-aspartic acid (NMDA) antagonists and non-NMDA antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the plus maze test in rats. In the present study, the effect of intracanalicular blockade of NMDA receptors using dizocilpine in the plus maze was studied in male rats bilaterally cannulated NAS.Methods:Rats were divided into five groups that received either 1 μL injections of saline or dizocilpine (MK-801, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine) in different doses (0.5, 1, 2, or 4 μg) 15 min before testing.Results:Time spent in the open arm increased under dizocilpine treatment with the two higher doses (2 and 4 μg, p