Determinants of immunological and virological responses to antiretroviral therapy amongst HIV infected adults in Central Argentina: negative influence of HCV infection.

FARÍAS A; KREMER L; ALLENDE L; DIAZ MP; PISANO MB; CONTIGIANI M; RÉ VE

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2013

0035-9203

Background: The purpose of this study was to update the epidemiological data of prevalence of coinfection HCV/HIV and to identify whether specific clinical and epidemiological factors influenced in response to HAART among HIV-positive adults. Methods: This is a retrospective observational cohort study of 238 HIV-infected patients to evaluate the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response to gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (associated of < 200 CD4cells/ml independently of viral load < or > to100 000 copies/ml), were significantly associated with immunological and virological response to HAART. Conclusions: These results show further evidence that hepatitis C serostatus is associated with poorer responses to HAART.