INVESTIGADORES
GONZALEZ Alejandro Hernan
artículos
Título:
Dynamical Characterization of Antiviral Effects in COVID-19
Autor/es:
ABUIN, PABLO; ANDERSON, ALEJANDRO; FERRAMOSCA, ANTONIO; HERNANDEZ VARGAS, ESTEBAN ABELARDO; GONZÁLEZ, ALEJANDRO HERNÁN; GONZÁLEZ, ALEJANDRO HERNÁN
Revista:
ANNUAL REVIEWS IN CONTROL
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2021
ISSN:
1367-5788
Resumen:
Mathematical models describing SARS-CoV-2 dynamics and the corresponding immune responses inpatients with COVID-19 can be critical to evaluate possible clinical outcomes of antiviral treatments. Inthis work, based on the concept of virus spreadability in the host, antiviral effectiveness thresholds aredetermined to establish whether or not a treatment will be able to clear the infection. In addition, thevirus dynamic in the host - including the time-to-peak and the final monotonically decreasing behavior - is chracterized as a function of the treatment initial time. Simulation results, based on nine real patient data, show the potential clinical benefits of a treatment classification according to patient critical parameters. This study is aimed at paving the way for the different antivirals being developed to tackle SARS-CoV-2.
