Antitumor effect of a Cu(II) complex with saccharinate and glutamine released from silica spheres

RIZZO, A.; ARNAL P.M.; ETCHEVERRY S.B.; SANTI, E.; TORRE, M.H.; DI VIRGILIO A.L.

Congreso; Antitumor effect of a Cu(II) complex with saccharinate and glutamine released from silica spheres; 2016

Metal complexes show diverse pharmacological effects. In particular, Cu(II) exerts essential functions in bone and in inflammatory processes underlying different illnesses as cancer. Its complexation with organic ligands favors the use of lower doses. Previously, we reported the antitumor effects of a complex of Cu(II) with saccharinate and glutamine (Cu-sac-gln). This complex showed promissory effects since it exerted a stronger cytotoxic action in human osteosarcoma cells (MG-63) than in a normal phenotype murine osteoblasts. The aim of this study was to demonstrate the beneficial effect of controlled release of Cu-sac-gln from a drug delivery system (SiO2 spheres). Monodisperse SiO2 spheres (diameter about 1 m) having micro and mesopores were synthesized according to a reported synthesis and characterized by SEM and N2 adsorption. Their biocompatibility was demonstrated by the MTT assay in MG-63 cells from 10 to 1000 µg/mL range (p