Oxidovanadium(IV) Complexes with Flavonoids: activation of NFkB and apoptosis in HT-29 cell line

LEÓN I.E.; PORRO V.; TISCORNIA I.; DI VIRGILIO A.L.; BOLLATI-FOGOLIN M.; ETCHEVERRY S.B.

Congreso; Molecular mechanisms in cell signaling and gene expression. SAIB 2013; 2013

Polyphenolic flavonoids present anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin exhibit anti-proliferative and anti-metastatic effects against various malignant cell lines. In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 μM while VOchrys only provoked this effect at 100 μM (p