Vanadium and cancer treatment: antitumoral mechanisms of three oxovanadium(IV) complexes on a human osteosarcoma cell line.

LEÓN I.E.; BUTENCO N.; DI VIRGILIO A.L.; MUGLIA C.I.; BARAN E.; CAVACO I.; ETCHEVERRY S.B.

JOURNAL OF INORGANIC BIOCHEMISTRY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2014 p. 106 - 117

0162-0134

Vanadium compounds present interesting biological and pharmacological properties. Organically chelated vanadium compounds are more potent to facilitate pharmacological actions than the simple vanadium salts. We report herein the antitumoral actions of three oxovanadium(IV)complexes on MG-63 human osteosarcoma cell line. The three complexes (VO(oda), VO(oda)bipy) and VO(oda)phen, caused a concentration dependent inhibition of cell viability. The antiproliferative action of VO(oda)phen could be observed in the whole range of concentrations (from 2.5 μM), while VO(oda)bipy and VO(oda) showed a decrease of cell viability only at higher concentrations (from 50 and 75 μM, respectively) (p