Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: role of the oxidative stress and apoptosis.

LEÓN I.E.; DI VIRGILIO A.L.; PORRO V.; MUGLIA C.I.; NASO L.G.; WILLIAMS P.A.M.; BOLLATI-FOGOLIN M.; ETCHEVERRY S.B.

DALTON TRANSACTIONS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2013 vol. 42 p. 11868 - 11880

1477-9226

Flavonoids, a polyphenolic compound family and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumoral actions of the complex VO(chrysin)2EtOH]2 (VOchrys) on MG-63 human osteosarcoma cell line. Chrysin and VOchrys caused an inhibition of cell viability in MG-63 tumor cells in a dose-response manner. Nevertheless, the antiproliferative action of the complex is much stronger than that of the free flavonoid in the whole range of concentrations (p