A new synthesis pathway for colloidal, TiO2-coated silica spheres. Comparative study on cyto- and genotoxic effects of a titanium-coated silica particles and titanium oxide nanoparticles in rat osteosarcoma (UMR106) cells.

DI VIRGILIO A.L.; MAISULS I.; KLEITZC F.; ARNAL P.M.

JOURNAL OF COLLOID AND INTERFACE SCIENCE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2013 vol. 394 p. 147 - 156

0021-9797

Spherical particles with an amorphous core of silica and a crystalline shell of titanium oxide (SiO2@TiO2) formed in a three-step procedure, being the last step a mild chemical treatment. SiO2@TiO2 had a shell with pores (micro and mesopores) permeating between TiO2 nanocrystals (anatase) and a solid core of amorphous silica. The spheres had an outstanding specific surface area (300 m2 g1). A cyto- and genotoxic study of SiO2@TiO2 and titanium oxide nanoparticles (TiO2-NP) on UMR106 cells with 24 h exposure showed that SiO2@TiO2 colloidal particles were less toxic than TiO2-NP.