Iodine intake adequacy and metabolic parameters in polycystic ovary syndrome patients.

ORTIZ I; ORTIZ G; VELEZ L; ALTAMIRANO J; PELLETÁN L; MARTINEZ A; GAMARRA LUQUES C; HAPON MB

San Luis

Congreso; XL Reunión Anual de la Sociedad de Biología de Cuyo; 2022

Sociedad de Biología de Cuyo

Polycystic Ovary Syndrome (PCOS) is multifactorial and frequent endocrinopathy in women. On the other hand, hypothyroidism is an endocrinopathy with a high prevalence in women, which impacts female reproduction and metabolism. Despite the high prevalence of thyroid disease in women with PCOS (10-30%), in our region, there is not a permanent epidemiological surveillance, considering that it is an area of iodine deficiency. Scientific bases confirm that women with PCOS that later became hypothyroid may have adverse outcomes on metabolism and fertility. It is worth to note that, this disorder is aggravated by iodine consumption deficiency which correlates with a higher prevalence of hypothyroidism. In view of the preceding, this study hypothesized that women with PCOS have a higher prevalence of metabolic disorders associated to iodine intake. To corroborate this, the goal of this study was to perform a prospective study carried out from a cohort of 42 women from 18 to 42 years old (PCOS n=11, Control n=31), who attended for infertility consultation at the Instituto de Medicina Reproductiva (IMR) or volunteers from Mendoza province. The presence of PCOS was determined according to the Rotterdam criteria: oligo-or anovulation, clinical and/or biochemical signs of hyperandrogenism, and/or polycystic ovaries on ultrasound. The following morphometric parameters were evaluated: age, height and body weight. Besides, the biochemical profile was assessed by the serum determination of total, LDL and HDL cholesterol, triglycerides, glucose, and urine iodine. Statistical analysis was performed by means of GraphPad Prism 7 software. The analysis showed that PCOS have a higher body mass index than controls (p=0.0076). With respect to the biochemical profile, PCOS patients showed lower levels of total cholesterol (p=0.038) due to the decrease of HDL cholesterol (p=0.0218). The glycemia, triglycerides and LDL cholesterol were not affected. Urine iodine in PCOS women is lower than controls (p=0.027). It is also noteworthy that 27.3% of PCOS patients present iodine insufficiency (