INVESTIGADORES
GAMARRA LUQUES Carlos Diego
artículos
Título:
Facile Synthesis of a Phototoxic Monofunctionalized Tetraarylporphyrin as Scaffold for Porphyrin-Quinone Conjugates
Autor/es:
SEREDA G, MOORTHY R, GAMARRA LUQUES C, TELLERIA C
Revista:
An International Journal for Rapid Communicationsof Sinthetic Organic Chemistry
Editorial:
Taylor & Francis
Referencias:
Lugar: Londres; Año: 2011 p. 1 - 22
ISSN:
1532-2432
Resumen:
A new carboxy-monofunctionalized tertraarylporphyrin has been tested for cytotoxicity toward OV2008 human ovarian cancer cells. This compound acutely inhibits growth of ovarian cancer cells only upon exposure to ambient light while suppresses long term clonogenic survival of cells under both dark and light stimulated conditions. Due to the variable length of the linkage between the anthraquinone and porphyrin moieties, the synthesized monocarboxylated porphyrin presents a versatile scaffold for fine-tuning of the photoelectron transfer in the quinone-porphyrin conjugate. To demonstrate its synthetic value, we converted the carboxy-derivative to its amino-counterpart.
