AEROBIC TRAINING-INDUCED MITOCHONDRIAL ADAPTATIONS IN HYPERTENSIVE MYOCARDIUM Godoy Coto J1, Yeves AM1, Pereyra EV1, Ennis IL1.

GODOY COTO J.; YEVES A.M.,; PEREYRA E,; ENNIS I.L.

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS SAIC - SAI - SAFIS 10 AL 13 DE NOVIEMBRE | 2020; 2020

Pathological cardiac remodeling occurs in essential hypertension and consists of ultra-structural alterations and mitochondrial dysfunction. Physiological cardiac adaptations occur in response to aerobic training to satisfy the work-load during exercise. Despite this, its beneficial effects on the mitochondria have not been completely elucidated in the hy-pertensive myocardium. Objective. To determine whether sustained swimming training improves myocardial mito-chondrial phenotype in spontaneously hypertensive rats (SHR). Methods. 3-month old SHR were randomized to sedentary (Sed) and trained (Swim) groups. After the swimming protocol (8 weeks, 5 days/week) the hearts were destined for transmission electron microscopy (TEM) imaging, RT-PCR analysis, or mitochondrial iso-lation. Results are expressed as mean±SEM (TEM as median-IQR) and are statistically different (p