INVESTIGADORES
YEVES Alejandra Del Milagro
congresos y reuniones científicas
Título:
NA+/H+ EXCHANGER 1 (NHE-1) HYPERACTIVITY IS NOT CRITICALLY INVOLVED IN PHYSIOLOGICAL CARDIAC HYPERTROPHY: ROLE OF AKT.
Autor/es:
YEVES AM,; VILLA-ABRILLE MC, ; NOLLY MB; PÉREZ NG; ESCUDERO EM ; ENNIS IL
Lugar:
San Diego, California
Reunión:
Congreso; XXI Internacional Society of Heart Research (ISHR) World Congress; 2013
Institución organizadora:
Internacional Society of Heart Research (ISHR)
Resumen:
Na+/H+ exchanger (NHE-1) hyperactivity is not critically involved in physiological cardiac hypertrophy: role of AKT. Yeves, AM; Villa-Abrille MC; Nolly, MB; Pérez, NG; Escudero, EM; Ennis, IL. Cardiovascular Research Center, UNLP-CONICET. Argentina. Background. NHE-1 hyperactivity plays a key role in pathological cardiac hypertrophy (CH) increasing intracellular Na+ and Ca2+ and favouring calcineurin activation. Moreover, NHE-1 specific inhibition prevents and/or regresses pathological CH. However, it has not been yet elucidated its putative involvement in physiological CH. Since myocardial stretch, the activator of NHE-1, is a common event in both types of hypertrophy, we speculate that NHE-1 hyperactivity should be involved in both. Methods. Physiological CH was induced in rats by swimming (90 min/day, 12 weeks) or in isolated cardiomyocytes with IGF-I (10 nmol/L). Results. Swimming induce cardiac hypertrophy [biventricular weight/tibia length: 22.0±0.3 vs. 24.3±0.7 mg/mm; sedentary (S) and trained (T); p
