EARLY INTRACELLULAR SIGNALS AFTER MYOCARDIAL STRETCH LEADING TO CARDIAC HYPERTROPHY. KEY ROLE OF NHE-1.

CINGOLANI HE1, ; PEREZ NG,; AIELLO EA,; ENNIS IL, ; GARCIARENA CD;; VILLA ABRILLE MC; DULCE RA,; CALDIZ CI; YEVES AM; CORREA M. V.;; NOLLY MB; CHIAPPE DE CINGOLANI GE

FRONTIERS IN BIOSCIENCE-LANDMARK

FRONTIERS IN BIOSCIENCE INC

Lugar: Albertson, NY, USA; Año: 2008 vol. 1 p. 7096 - 7114

1093-9946

Front Biosci. 2008 May 1;13:7096-114. Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. Cingolani HE1, Perez NG, Aiello EA, Ennis IL, Garciarena CD, Villa-Abrille MC, Dulce RA, Caldiz CI, Yeves AM, Correa MV, Nolly MB, Chiappe de Cingolani G. Author information 1Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900 La Plata, Argentina. cicmes@infovia.com.ar Abstract The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCX(rev)), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.